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DOI:
Influence of gender and strain on formalin test using kunming, BALB/c and C57BL/6 Mice
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Abstract:
Objective To explore the effects of gender and stain on formalin test in mice. Methods Analyzing the licking/biting time of male and female Kunming,BALB/c and C57BL/6 mice in formalin test. Results (1)In the earlyphase of formalin test, there was no difference among all animal groups. In the late--phase, 20± 25 min,the licking/biting time of male Kunming mice (23.25± 17.27)s was significantly less than that of C57BL/6 (63.33± 18. 20)s, and the licking/biting time of female Kunruing mice (64.63± 52.71)s was significantly longer than that of BALB/c (17.00± 22.34)s or CATBL/6 (32. 17±27, 42)s at 20-25 min. The licking/biting time of female C57BL/6 mice at 50-55 min (0. 83± 1.33)s was significantly less than that of Kunming mice (47.50±51.03)s. (2)The licking/biting time of male Kunming mice (23. 25±17.27)s was significantly less than that of female mice (64.63±52. 71)s. The licking/biting time of male C57BL/6 mice (63.33 ±18.20)s was significantly more than that of fe- male mice (22. 83±118. 41)s. Conclusions Gender and strain could significantly affect the licking/biting time of mice in formalin test. To increase the reliability of the test,male mice should be chosen.
Key words:  Mice  Pain measurement  Sex factors  Strain

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