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DOI:10.3969/j.issn.1009-6574.2017.03.007
Correlation between cognitive function and event-related potential P300 in male long-term hospitalized patients with schizophrenia
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Abstract:
Objective To investigate the relationship between cognitive function and event-related potential P300 in male long-term hospitalized patients with schizophrenia. Method Totals of 82 male long-term hospitalized patients with schizophrenia and 52 healthy controls were recruited. The event-related potential P300 was analyzed by the United States Nicolet Viking Quest evoked potential instrument.The cognitive function was tested by animal naming test,category fluency test,digital cancellation test,trail taking test (TMT-A,TMT-B),stroop test (word,colour,word-colour interference test),block design test and WMS-Ⅲspatial span test. Results There were significant differences between patient group and controlgroup in all items of cognitive function assessment scales (P<0.01) . There were longer latency of P300 (t=22.990,P <0.01) and lower amplitude of P300 (t=-9.699,P <0.01) in patient group than that in control group. The P300latency was positively correlated with digital cancellation test and the score of TMT-A in patient group (r=0.481,P<0.01;r=0.245,P<0.05). Moreover,P300 amplitude was negatively correlated with digital cancellation test in patient group (r= -0.338,P<0.01). Conclusion The male long-term hospitalized patients with schizophrenia still have cognitive impairment,even when their psychiatric symptoms are stable. The latency and amplitude of event-relatedpotential P300 may be an electrophysiological marker of cognitive function in schizophrenic patients,which were correlated with the results in the cognitive assessment scales.
Key words:  Schizophrenia  Event-related potentials,P300  Cognitive function

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