|Effect of computerized cognitive remediation therapy combined with social skills training oncognitive function in schizophrenic patients
|Objectives To investigate the effects of computerized cognitive remediation therapy
combined with social skills training on cognitive function in schizophrenic patients. Methods From January
to December 2017， totally 168 patients with chronic schizophrenia were randomly divided into the intervention
group（ 82 patients enrolled， 79 patients retained） and the control group（ 86 patients enrolled， 84 patients
retained）. They received a 12-week computerized cognitive remediation therapy combined with social skills
training and only computer cognitive remediation therapy， respectively. They were followed up for 12 months.
The Positive and Negative Symptoms Scale（ PANSS）， the Chinese version of the MATRICS Consensus Cognitive
Battery（ MCCB）， and the Personal and Social Performance Scale（ PSP） were evaluated at baseline， at the end
of 12 weeks， and at the end of 12 months. Results （1） At the end of the 12-week treatment， the cognitive
factor scores of the PANSS scale in the intervention group were significantly lower than those in the control
group（ t=-4.22， P＜0.001）. The negative factor scores and cognitive factor scores in the intervention group at
the end of 12 months were significantly lower than the control group（ t=-2.36，P=0.020；t=-5.91，P＜0.001）.
At the end of 12 months， the PANSS total score of the intervention group was significantly different from the
baseline（ t=3.41，P＜0.001）， but there was no significant difference compared with the control group（ t=1.57，
P=0.119）.（ 2） There were significant differences in PSP total score， total neurocognitive function score and
social cognition score between the intervention group and the control group at the end of 12 months（ P＜0.05）.
Conclusions Computerized cognitive remediation therapy combined with social skills training can significantly
improve the cognitive function of patients with schizophrenia， thus effectively promoting the recovery of social
|Key words: Schizophrenia Cognitive function Computer cognitive remediation therapy Socialskills training